Projects

2020

Funding: Medical Research Agency grant (grant number 2019/ABM/01/00037)

Project duration: : 2020-2026

Amount: EUR 6,948,000

Project summary: National, multicenter, randomized, double-blind, parallel-group, stratified by SGLT-2 inhibitor type, placebo-controlled trial, – a Phase III study. The primary objective is to investigate the impact of SGLT-2 inhibitors (Empagliflozin and Dapagliflozin) on primary and secondary clinical endpoints in patients with acute/decompensated HF with and without type 2 diabetes mellitus within 78 weeks after the event. Non-commercial, randomized, double blind clinical trial.

Collaborators:

  1. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
  2. Bielanski  Father Jerzy Popiełuszko Hospital, Independent Public Heath Care Facility in Warsaw
  3. Regional Multispecialist Hospital in Kielce
  4. Medical University of Łódź
  5. Medical University of Gdańsk
  6. Independent Public Specialized Health Care Facility, St. John Paul II Zachodni Hospital in Grodzisk Mazowiecki
  7. Nicolaus Copernicus University in Toruń
  8. University Hospital of the Medical University in Poznań
  9. Department of Interventional Cardiology, Institute of Cardiology,  Collegium Medicum, Jagiellonian University Specialized John Paul II  Hospital  in Kraków
  10. Medical University of Wrocław
  11. Medical University of Białystok
  12. Medical University of Silesia
  13. Medical University of Vienna
  14. Medical University of Graz
  15. University Hospital Center of Medical University of Warsaw

Funding: Club 30 of the Polish Cardiac Society

Project duration: 2020 – 2022 (24 months)

Amount: EUR 12,000

Project summary: Prospective, observational, multicentre study to develop a novel biomarker for early identification of patients with subclinical leaflet stenosis after transcatheter aortic valve implantation based on platelet extracellular vesicles.

Collaborators:

  1. 1st Chair and Department of Cardiology, Medical University of Warsaw
  2. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
  3. Department of Cardiology, Hospital Nowa Sól, Zielona Góra University, Zielona Góra, Poland
  4. 1st Department of Cardiology, Medical University of Gdańsk, Gdańsk, Poland
  5. Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland
  6. Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam, The Netherlands

Funding: Club 30 of the Polish Cardiac Society

Project duration: 2020 – 2021 (6 months)

Amount: EUR 10,000

Project summary: Prospective, observational, multicentre study to develop a novel biomarker for early identification of patients before the onset of an occlusive coronary thrombus and irreversible damage of the cardiac muscle based on platelet extracellular vesicles.

Collaborators:

  1. 1st Chair and Department of Cardiology, Medical University of Warsaw;
  2. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland;
  3. Department of Cardiology, Hospital Nowa Sól, Zielona Góra University, Zielona Góra, Poland;
  4. Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam, The Netherlands;
  5. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands

2019

Title: Evaluation of prognostic value of platelet-derived extracellular microvesicles and microRNA in patients witch ischemic stroke of undetermined source- ESUS. 

Funding: Polish National Science Centre research grant (grant number 2018/31/B/NZ7/01137).

Project duration: 2019-2023

Amount: EUR 418,000

Project Summary: The main objective of this study is to characterize platelet-derived extracellular vesicles (PEV) and peripheral blood miRNAs (both PEVs-related and circulating profiles) in patients with embolic stroke of undetermined source (ESUS) in order to analyze their diagnostic and prognostic utility

Collaborators:

  1. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
  2. Department of Medical and Surgical Sciences, Magna Graecia University,
    University of Catanzaro, Italy 
  3. Laboratory of Experimental Clinical Chemistry, and Vesicle Observation Centre, Academic Medical Centre of University of Amsterdam 
  4. Genetic and Molecular Epidemiology Laboratory, McMaster University Hamilton, Canada, Division of Cardiology

Funding: National Science Centre

Project number: 2018/31/N/NZ7/02260

Project duration: 2019 –2022 (36 months)

Amount: EUR 50,000

Project summary: Prospective, observational, multicentre study to determine the effect of novel, potent antiplatelet drugs, ticagrelor and prasugrel on circulating platelet-derived microRNAs in relation to platelet reactivity in the acute phase of acute coronary syndrome, and to investigate whether combined evaluation of circulating platelet-derived miRNAs and platelet reactivity improves the prediction of recurrent ischaemic events over 3 years observation.

Collaborators:

  1. 1st Chair and Department of Cardiology, Medical University of Warsaw
  2. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
  3. Department of Cardiology, Medical University of Vienna, Vienna, Austria
  4. Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam, The Netherlands

2017

Funding: Polish National Science Centre research grant (grant number 2017/25/N/NZ5/00545).

Project duration: 2017-2021

Amount: EUR 72,000

Summary: The main objective of this project is to study and characterize platelet extracellular vesicles and circulating platelet-derived microRNAs in relation to platelet reactivity in patients with embolic stroke with large artery atherosclerosis in the acute phase of the disease and up 30-days after events during acetylsalicylic acid (ASA) therapy.

Collaborators: 

  1. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
  2. Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, University of Catanzaro, Italy 
  3. Laboratory of Experimental Clinical Chemistry, and Vesicle Observation Centre, Academic Medical Centre of the University of Amsterdam

Funding: Ministry of Science and Higher Education “Diamentowy Grant” research grant (grant number 072/DIA/2017/46).

Duration: 2017-2021

Amount: EUR 72,000

Project summary: The main objective of this project is to study and characterize novel microRNAs in type 2 diabetes patients and its potential role as a diagnostic and prognostic biomarker of platelets reactivity and cardiovascular event

Collaborators:

  1. Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
  2. Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, University of Catanzaro
  3. Department of Cardiology, Medical University of Vienna, Vienna, Austria